RESUMO
Vaccine hesitancy became an important topic in the public discourse and academic research during the COVID-19 pandemic, but its history is as long as the history of immunization. One can find the same determinants of vaccine hesitancy, though in variable proportions, since the 1721 Boston smallpox epidemic. We aim to describe several historical immunization moments and analyze them using the vaccine hesitancy framework of the "5Cs" (ie, confidence, complacency, constraints, risk calculation, and collective responsibility).
Assuntos
COVID-19 , Pandemias , Humanos , Hesitação Vacinal , COVID-19/prevenção & controle , VacinaçãoRESUMO
Vaccine hesitancy became an important topic in the public discourse and academic research during the COVID-19 pandemic, but its history is as long as the history of immunization. One can find the same determinants of vaccine hesitancy, though in variable proportions, since the 1721 Boston smallpox epidemic. We aim to describe several historical immunization moments and analyze them using the vaccine hesitancy framework of the "5Cs" (ie, confidence, complacency, constraints, risk calculation, and collective responsibility).
Assuntos
COVID-19 , Pandemias , Humanos , Hesitação Vacinal , COVID-19/prevenção & controle , VacinaçãoRESUMO
Trauma during pregnancy is the leading non-obstetric cause of morbidity and mortality, and accounts for five per 1000 fetal deaths. Direct fetal injury due to trauma during pregnancy is rare, and limited information is available about how to optimize fetal outcomes after injury. Early recognition and appropriate management of direct fetal trauma may improve outcomes for the fetus. There are currently no available guidelines to direct management of the injured fetus. We provide a detailed literature review of the management and outcomes of direct fetal injury following blunt and penetrating injury during pregnancy, and describe a suggested initial approach to the injured pregnant patient with a focus on evaluation for fetal injury. We identified 45 reported cases of blunt trauma resulting in direct fetal injury, with 21 surviving past the neonatal period, and 33 of penetrating trauma resulting in direct fetal injury, with 24 surviving past the neonatal period. Prenatal imaging identified fetal injury in 19 cases of blunt trauma and was used to identify bullet location relative to the fetus in 6 cases. These reports were used to develop management algorithms for the injured fetus.
Assuntos
Complicações na Gravidez , Ferimentos não Penetrantes , Ferimentos Penetrantes , Feminino , Morte Fetal , Feto , Humanos , Recém-Nascido , Gravidez , Estudos Retrospectivos , Ferimentos não Penetrantes/diagnóstico por imagem , Ferimentos não Penetrantes/terapia , Ferimentos Penetrantes/diagnóstico por imagem , Ferimentos Penetrantes/terapiaRESUMO
Inguinal hernia is a common problem affecting infants in the NICU. As a group, preterm infants have the highest incidence of inguinal hernia and this risk increases as gestational age decreases. The etiopathologic factors leading to the development of an inguinal hernia are not clear and interventions to alter these factors have not been thoroughly investigated. Diagnosis of an inguinal hernia is often straightforward, but occasionally it may be difficult to determine if the hernia is strangulated or simply obstructed. Rarely, investigative modalities, such as ultrasonography, may be needed to rule out other potential causes. The ideal timing of surgical repair in this population is unknown and complicated by comorbid conditions and limited randomized controlled trials. During surgery, the choice of regional versus general anesthesia requires a team-based approach and studies have found that greater clinical experience is associated with lower morbidity. The techniques of hernia surgery range from open to laparoscopic repair and have been investigated in small prospective studies, while larger databases have been used to analyze outcomes retrospectively.
